Bharat Biotech International Ltd has launched Hillchol (BBV131), a novel single-strain oral cholera vaccine (OCV) developed under license from Hilleman Laboratories. This launch is critical as global demand for OCVs exceeds 100 million doses annually, and there has been a deficit of approximately 40 million doses due to limited supply.
Global Cholera Vaccine Shortage
With cholera cases and deaths rising since 2021, the need for OCVs has become more urgent. Currently, only one manufacturer supplies these vaccines worldwide, contributing to the significant shortfall.
Vaccine Details
Hillchol is administered orally on Day 0 and Day 14 and is suitable for individuals over one year of age. Available in a single-dose respule, the vaccine requires storage between +2°C and +8°C. Bharat Biotech’s manufacturing facilities in Hyderabad and Bhubaneswar can produce up to 200 million doses annually, aiming to address the global vaccine shortage.
Collaborative Development
The vaccine was developed through a collaboration between Hilleman Laboratories, Bharat Biotech, the University of Gothenburg, and Gotovax AB. The initiative aligns with the Global Task Force on Cholera Control’s (GTFCC) goal of reducing cholera-related deaths by 90% by 2030.
Bharat Biotech International Ltd: Key Points
Founded: 1996
Headquarters: Hyderabad, India
Specialization: Vaccine development, production, and distribution
Notable Products: Covaxin (COVID-19 vaccine), Rotavac (rotavirus vaccine), Typbar TCV (typhoid vaccine), Hillchol (oral cholera vaccine)
Global Impact: Supplies vaccines to over 123 countries, known for pioneering affordable vaccines for global health
Research & Development: Focuses on innovative vaccine technologies, with partnerships in both public and private sectors
Manufacturing Capacity: State-of-the-art facilities with large-scale production capabilities, including a capacity of up to 200 million doses annually for Hillchol
Regulatory Approvals: Approved by major global health organizations, including WHO and national regulatory authorities
Recent Achievement: Launched Hillchol (BBV131), a novel oral cholera vaccine developed in collaboration with Hilleman Laboratories in 2024.
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